Over 1.5 mg MDMA per kg body weight for men and 1.3 mg per kg body weight for women is too much (ex. woman 60 kg x 1.3 =max. 78 mg MDMA). Side effects such as jaw grinding, eye and muscle twitching, or seizures may occur. In overdoses, body temperature rises sharply and hallucinations may occur. On subsequent days, after taking such high doses of MDMA, increased depression, lack of concentration, sleep disturbances, loss of appetite, and a feeling of strong listlessness occur. Regular use of large amounts of MDMA is neurotoxic and increases the likelihood of irreparable brain damage.